Valgestril 21 tablets

Available at Pharmaegy Pharmacy. Use as directed by your doctor.

Valgestril 21 tablets Composition: 10 brown tablets: Estradiol valerate 2 mg, Norgestrel 0.5 mg 11 white tablets: Estradiol valerate 2 mg. Description: Combined hormone replacement therapy (HRT) for peri- and postmenopausal women. Contains estrogen (estradiol valerate) and progestogen (norgestrel). Alleviates menopausal symptoms and prevents osteoporosis. Indications: - Menopausal symptoms: hot flashes, night sweats, sleep disturbances, mood swings. - Urogenital atrophy (vaginal dryness, dyspareunia). - Prevention of osteoporosis in high-risk women. - Menstrual disorders (amenorrhea, dysmenorrhea) in women with intact uterus. Dosage and Administration: Initiation: With cyclic menstruation: on day 5 of the cycle. With amenorrhea: any day. Regimen: 1 tablet daily for 21 days (white then brown), then 7-day break. Time: Same time daily, with or without food. Contraindications: - Breast cancer or estrogen-dependent tumors (including history). - Undiagnosed vaginal bleeding. - History of thrombosis (venous/arterial). - Severe liver disease. - Porphyria, hypertriglyceridemia. - Pregnancy, lactation. - Hypersensitivity to ingredients. Precautions: - Cancer risk: Regular breast monitoring (mammography every 1-2 years). - Thrombosis: Assess benefits/risks in high-risk patients (obesity, smoking, thrombophilia). - Pre-treatment screening: BP, lipids, glucose, liver function. Interactions: Reduce efficacy: barbiturates, rifampicin, St. John’s wort. Increase efficacy: ketoconazole, antidepressants. Lactose: Contains lactose — contraindicated in intolerance. Adverse Effects: Common (>1%): Breast tenderness, headache, nausea, breakthrough bleeding. Mood swings, weight gain. Rare (<0.1%): Thrombosis, hypertriglyceridemia, chloasma (skin pigmentation). Increased growth of uterine fibroids. Discontinue immediately if: Migraine, jaundice, chest pain. Pregnancy and Lactation: Contraindicated. Discontinue immediately if pregnancy occurs. Storage: Store below 30°C in a dry place. Package: A carton box containing a blister of 21 tablets (11 white + 10 brown) + leaflet.