Megamox ES 642.9 mg / 5 ml suspension 100 ml

Available at Pharmaegy Pharmacy. Use as directed by your doctor.

Megamox ES 600 mg/5 ml 42.9 mg/5 Composition: Amoxicillin 600 mg/5 ml (as trihydrate) Clavulanic acid 42.9 mg/5 ml (as potassium salt) Description: Megamox ES is a combination antibiotic containing amoxicillin, a penicillin-class antibacterial, and clavulanic acid, a beta-lactamase inhibitor. This formulation is designed to treat infections caused by susceptible bacteria and reduce the development of drug-resistant strains. It is supplied as a powder for oral suspension and must be reconstituted before use. Indications: Megamox ES is indicated for the treatment of pediatric patients with recurrent or persistent acute otitis media caused by: -Streptococcus pneumoniae (penicillin MICs ≤ 2 mcg/ml) -Haemophilus influenzae (including beta-lactamase-producing strains) -Moraxella catarrhalis (including beta-lactamase-producing strains) Dosage and Administration: Pediatric patients (3 months and older): 90 mg/kg/day of amoxicillin component divided every 12 hours for 10 days. (This provides 6.4 mg/kg/day of clavulanic acid.) 8kg- 3.0 ml twice daily 12kg- 4.5 ml twice daily 16kg- 6.0 ml twice daily 20kg- 7.5 ml twice daily 24kg- 9.0 ml twice daily 28kg-10.5 ml twice daily 32kg-12.0 ml twice daily 36kg-13.5 ml twice daily Pediatric patients > 40 kg and Adults: Experience is not available. Adults should not substitute Megamox ES for tablet formulations. Patients with hepatic impairment: Use with caution and monitor hepatic function regularly. Preparation of Suspension: Tap bottle to loosen powder. Add approximately 2/3 of the total water for reconstitution, shake vigorously. Add the remaining water up to the marked line, shake vigorously again. Each 5 ml after reconstitution contains: 600 mg amoxicillin + 42.9 mg clavulanic acid. Important: Shake well before each use. Administration: Take at the start of a meal to minimize gastrointestinal discomfort and enhance clavulanic acid absorption. Contraindications: -History of serious hypersensitivity reactions (e.g., anaphylaxis, Stevens-Johnson syndrome) to amoxicillin, clavulanate, penicillins, or cephalosporins. -History of cholestatic jaundice or hepatic dysfunction associated with amoxicillin/clavulanic acid use. Warnings and Precautions: -Monitor for signs of hypersensitivity reactions. Discontinue if allergic reactions occur. -Use with caution in patients with hepatic impairment. Side Effects: Side effects associated with Megamox ES may include: -Serious hypersensitivity reactions, including: Anaphylaxis, Stevens-Johnson syndrome -Jaundice (especially cholestatic jaundice) -Hepatic dysfunction -If signs of an allergic reaction (rash, itching, facial swelling, or difficulty breathing) or symptoms of liver dysfunction (yellowing of the skin or eyes, dark urine) occur, the use of the medication should be discontinued immediately, and medical attention should be sought. Storage Conditions: Store reconstituted suspension in a refrigerator (2–8°C). Discard after 10 days. Packaging: A carton contains one bottle of powder for reconstitution to 100 ml suspension and a package insert.