Spectone 100 mg 20 tablets

Available at Pharmaegy Pharmacy. Use as directed by your doctor.

Spectone Compound: Each tablet contains: Spironolactone 100 mg Properties: Potassium-, magnesium-sparing diuretic. It is a competitive aldosterone antagonist in terms of its effect on the distal nephron (competes for binding sites on cytoplasmic protein receptors, reduces the synthesis of permeases in the aldosterone-dependent region of the collecting ducts and distal tubules), increases the excretion of Na +, Cl- and water and reduces the excretion of K + and urea, reduces the titratable acidity of urine. Increased diuresis causes a hypotensive effect, which is unstable. The hypotensive effect does not depend on the level of renin in the blood plasma and does not appear in normal blood pressure. The diuretic effect is manifested on the 2nd-5th day of treatment. Indications: Edema in chronic heart failure, cirrhosis of the liver (especially with the simultaneous presence of hypokalemia and hyperaldosteronism), with nephrotic syndrome. Edema in the II and III trimesters of pregnancy. Arterial hypertension, incl. with aldosterone-producing adrenal adenoma (as part of combination therapy). Primary hyperaldosteronism. Aldosterone-producing adrenal adenoma (long-term maintenance therapy in case of contraindication to surgical treatment or in case of refusal of it). Diagnosis of hyperaldosteronism. Hypokalemia and its prevention in the treatment of saluretics. Polycystic ovary syndrome, premenstrual syndrome. Dosage and administration: Set individually depending on the severity of violations of water-electrolyte metabolism and hormonal status. Adults: With edematous syndrome – 100-200 mg / day (less often – 400 mg / day) in 2-3 doses daily for 14-21 days. Dose adjustment should be carried out taking into account the values ​​of the concentration of potassium in the plasma. If necessary, courses are repeated every 10-14 days. Children: 3 mg / kg in a separate dose. Contraindications: Addison’s disease, hyperkalemia, hypercalcemia, hyponatremia, chronic renal failure, anuria, liver failure, diabetes mellitus with confirmed or suspected chronic renal failure, diabetic nephropathy, first trimester of pregnancy, metabolic acidosis, menstrual irregularities or breast enlargement, hypersensitivity to spironolactone . Precautionary measures: Use with caution in AV blockade (the possibility of increased due to the development of hyperkalemia), decompensated liver cirrhosis, surgical interventions, taking drugs that cause gynecomastia, when taking local and general anesthetics, in elderly patients. Against the background of the use of spironolactone, preparations containing potassium, as well as other diuretics that cause potassium retention in the body, should not be prescribed. The use of spironolactone with carbenoxolone, which causes sodium retention, should be avoided. During the period of treatment, periodic determination of the content of electrolytes and urea in the blood should be carried out. Side effects: From the digestive system: nausea, vomiting, abdominal pain, gastritis, ulceration and bleeding in the gastrointestinal tract, intestinal colic, diarrhea or constipation. From the side of the central nervous system: dizziness, drowsiness, lethargy, headache, lethargy, ataxia. From the side of metabolism: an increase in the concentration of urea, hypercreatininemia, hyperuricemia, impaired water-salt metabolism and acid-base balance (metabolic hypochloremic acidosis or alkalosis). From the hemopoietic system: megaloblastosis, agranulocytosis, thrombocytopenia. From the endocrine system: with prolonged use – gynecomastia, erectile dysfunction in men; in women – dysmenorrhea, amenorrhea, metrorrhagia in menopause, hirsutism, coarsening of the voice, soreness of the mammary glands, breast carcinoma. Allergic reactions: urticaria, maculo-papular and erythematous rashes, drug fever, itching. Other: muscle spasms, decreased potency. Storage method: Store at a temperature of 15-25 degrees. In a place protected from light. Package: The cardboard box contains 2 blisters of 10 tablets, paper instructions.