Flagyl 125 mg / 5 ml 100 ml suspension

Available at Pharmaegy Pharmacy. Use as directed by your doctor.

Tradename: Flagil Flagyl Compound: Each 100 ml of suspension contains: Metronidazole benzoate 4.000 g. Auxiliary components: Ethanol, sucrose, methyl parahydroxybenzoate, propyl parahydroxybenzoate, lemon oil concentrate, purified water. Properties: Antiprotozoal and antimicrobial drug derived from 5-nitroimidazole. The mechanism of action consists in the biochemical reduction of the 5-nitro group by intracellular transport proteins of anaerobic microorganisms and protozoa. The reduced 5-nitro group interacts with deoxyribonucleic acid (DNA) of microbial cells, inhibiting the synthesis of their nucleic acids, which leads to the death of bacteria. Active against Trichomonas vaginalis, Entamoeba histolytica, as well as gram-negative anaerobes Bacteroides spp. (including Bacteroides fragilis, Bacteroides distasonis, Bacteroides ovatus, Bacteroides thetaiotaomicron, Bacteroides vulgatus), Fusobacterium spp. and some gram-positive anaerobes (sensitive strains Eubacterium spp., Clostridium spp., Peptococcus niger., Peptostreptococcus spp.). The minimum inhibitory concentration for these strains is 0.125-6.25 μg/ml. In combination with amoxicillin, it is active against Helicobacter pylori (amoxicillin inhibits the development of resistance to metronidazole). Aerobic microorganisms and facultative anaerobes are not sensitive to metronidazole, but in the presence of mixed flora (aerobes and anaerobes), metronidazole acts synergistically with antibiotics that are effective against conventional aerobes. Increases the sensitivity of tumors to radiation, induces sensitization to alcohol (disulfiram-like action), and stimulates reparative processes. Indications: Protozoal infections: extraintestinal amebiasis, including amoebic liver abscess, intestinal amebiasis (amoebic dysentery), trichomoniasis (including trichomonas vaginitis, trichomonas urethritis). Infections caused by Bacteroides spp. (including Bacteroides fragilis, Bacteroides distasonis, Bacteroides ovatus, Bacteroides thetaiotaomicron, Bacteroides vulgatus): infections of bones and joints, infections of the central nervous system (CNS), incl. meningitis, brain abscess, bacterial endocarditis, pneumonia, empyema and lung abscess, sepsis. Infections caused by the species Clostridium spp., Peptococcus niger and Peptostreptococcus spp.: infections of the abdominal cavity (peritonitis, liver abscess), infections of the pelvic organs (endometritis, abscess of the fallopian tubes and ovaries, infections of the vaginal vault). Pseudomembranous colitis (associated with the use of antibiotics). Gastritis or duodenal ulcer associated with Helicobacter pylori. Prevention of postoperative complications (especially interventions on the colon, near-rectal region, appendectomy, gynecological operations). Radiation therapy for patients with tumors – as a radiosensitizing agent, in cases where tumor resistance is due to hypoxia in tumor cells. Method of administration and dosage: With amebiasis inside Adults – 1.5 g / day for 3 doses and 30-40 mg / kg / day also for 3 doses (children) for 7 days. With giardiasis – adults – 750-1000 mg/day, up to five days. children 2–5 years old – 250 mg/day. children 5-10 years old – 375 mg/day. 10-15 years – 500 mg/day for 5 days. With trichomoniasis in women (urethritis and vaginitis) – once in a dose of 2 g or as a course of treatment for 10 days – 250 mg 2 times a day and 1 vaginal suppository a day. With Trichomonas urethritis in men – once in a dose of 2 g or as a course of treatment for 10 days, 250 mg 2 times a day. For nonspecific vaginitis – 500 mg 2 times a day for a week. For anaerobic infections, adults – 1-1.5 g / day, children – at the rate of 20-30 mg / kg / day. Intravenous administration is indicated only if it is impossible to take it in another way or in severe forms of diseases. 100 ml (500 mg) of the drug is administered over 30-60 minutes. Contraindications: Hypersensitivity. Precautionary measures: Long-term treatment is desirable under the control of the blood count. A false positive Nelson test is possible, since treponemas are immobilized. Combine with caution with indirect anticoagulants, non-depolarizing muscle relaxants. During treatment, the use of alcoholic beverages should be excluded. Side effects: Nausea, metallic taste in the mouth, anorexia, epigastric pain, vomiting, diarrhea, headache, dizziness, allergic reactions (urticaria, itching), leukopenia, peripheral neuropathies, with long-term treatment with large doses, brown-reddish coloration of urine is possible. Storage method: At a temperature not higher than 25 C. Package: The cardboard box holds a 100 ml glass bottle, paper instructions.