Kolovatil 30 tablets

Available at Pharmaegy Pharmacy. Use as directed by your doctor.

Trade name: Kolovatil Colovatil Compound: Each tablet contains: Sulpiride 25 mg Mebeverine hydrochloride 100 mg Auxiliary components: Microcrystalline cellulose, anhydrous lactose, talc, magnesium stearate, titanium dioxide. Properties: Mebeverin is a myotropic antispasmodic that has a direct effect on the smooth muscles of the gastrointestinal tract without affecting normal intestinal motility. The exact mechanism of action is unknown, but multiple mechanisms such as decreased ion channel permeability, blockade of norepinephrine reuptake, local anesthetic effects, and altered water absorption may cause mebeverine to act locally on the gastrointestinal tract. Through these mechanisms, mebeverine exhibits an antispasmodic effect, normalizing intestinal motility and not causing permanent relaxation of smooth muscle cells of the gastrointestinal tract (“hypotension”). Sulpiride has a moderate antipsychotic activity in combination with a stimulating and thymoanaleptic (antidepressive) action. The neuroleptic effect is associated with antidopaminergic action. In the central nervous system, sulpiride mainly blocks the dopaminergic receptors of the limbic system, and has little effect on the neostriatal system, it has an antipsychotic effect and causes a small number of side effects. The peripheral action of sulpiride is based on the inhibition of presynaptic receptors. An increase in the amount of dopamine in the central nervous system is associated with an improvement in mood, with a decrease in the development of symptoms of depression. Indications: Functional disorder of the gastrointestinal tract. Gastrointestinal colic (intestinal, bilious). Irritable Bowel Syndrome. diverticular disease. Post-dysenteric colitis. Control of gastrointestinal manifestations accompanying psychogenic and migraine headache.Dosage and administration: Take 1 tablet 3 times a day. Contraindications: Hypersensitivity to mebeverine or sulpride, mental disorders, age up to 18 years; pregnancy, breastfeeding period. Side effects: From the skin and subcutaneous tissues: urticaria (allergic rash), angioedema (serious allergic reaction, which may include: difficulty breathing, swelling of the face, neck, lips, tongue, throat), swelling of the face, exanthema (skin rash). From the immune system: hypersensitivity reactions (anaphylactic reactions – serious allergic reactions that may include difficulty breathing, rapid heart rate, a sharp decrease in blood pressure (weakness and dizziness), increased sweating). Drowsiness and confusion are also possible. Storage method: At a temperature not higher than 30 degrees. In a dry place. Package: The cardboard box contains 3 blisters of 10 tablets, paper instructions.