Cymbatex 60 mg 30 capsules

Available at Pharmaegy Pharmacy. Use as directed by your doctor.

Cymbatex 60 mg 30 Hard Gelatin Capsules Composition: Active ingredient: Duloxetine Hydrochloride 67.3 mg (equivalent to Duloxetine 60 mg) Description: Cymbatex is a delayed-release capsule containing duloxetine, a serotonin and noradrenaline reuptake inhibitor (SNRI). It has weak inhibition of dopamine reuptake and negligible affinity for other receptors. It increases extracellular serotonin and noradrenaline levels and modulates pain pathways in the central nervous system. Indications for Use: Major depressive disorder (MDD) Diabetic peripheral neuropathic pain Generalized anxiety disorder (GAD) in adults Dosage and Method of Administration: MDD: Start and maintain at 60 mg once daily, with or without food. Max: 120 mg/day. GAD: Start at 30 mg once daily; increase to 60 mg. Max: 120 mg/day. Diabetic Neuropathy: Start and maintain at 60 mg/day. Max: 120 mg/day in divided doses. Elderly: No adjustment needed, but caution at high doses. Children: Not recommended. Hepatic impairment: Contraindicated. Renal impairment: Avoid in severe impairment (<30 ml/min). Discontinuation: Taper gradually over at least 1–2 weeks. Administration: For oral use. Contraindications: Hypersensitivity to duloxetine or excipients Use with non-selective, irreversible MAOIs Liver disease with hepatic impairment Concomitant use with CYP1A2 inhibitors (e.g., fluvoxamine, ciprofloxacin) Severe renal impairment (<30 ml/min) Uncontrolled hypertension Precautions: Use caution in patients with bipolar disorder, seizures, increased intraocular pressure, or cardiac conditions Monitor blood pressure and heart rate Avoid abrupt discontinuation Increased risk of suicidal thoughts in early treatment, especially in young adults Risk of hyponatremia, especially in elderly or those on diuretics Risk of serotonin syndrome, akathisia, and SIADH Avoid in children and adolescents Side Effects: Very common: Nausea, dry mouth, headache, somnolence Common: Insomnia, dizziness, decreased appetite, constipation, fatigue, blurred vision, increased sweating Uncommon to rare: Suicidal ideation, mania, mydriasis, liver injury, hyponatremia, Stevens-Johnson syndrome, aggression, hallucinations, sexual dysfunction, orthostatic hypotension, urinary retention, weight changes Withdrawal symptoms (e.g., dizziness, agitation, insomnia) may occur upon discontinuation. Pregnancy and Breastfeeding: Not recommended during breastfeeding; limited data in infants Duloxetine passes into breast milk in low amounts Storage Conditions: Store in a dry place at temperature not exceeding 30°C. Keep out of reach of children. Packaging: Carton box containing 3 blister 10 hard gelatin capsules and a leaflet insert.