Alzmenda oral drops 10 mg 20 ml
Available at Pharmaegy Pharmacy. Use as directed by your doctor.
Trade Name: Alzmenda Composition: Each gram of solution contains: Memantine hydrochloride 10 mg Inactive ingredients: Sorbitol 70%, Propylene Glycol, Methylparaben, Propylparaben, Sodium Citrate, Water. Properties: A remedy for the treatment of dementia. It is a non-competitive antagonist of glutamate NMDA receptors (including in the substantia nigra), as a result, it reduces the excessive stimulating effect of cortical glutamate neurons on the neostriatum, which develops against the background of insufficient release of dopamine. By reducing the flow of Ca2+ into neurons, it reduces the possibility of their destruction. It has a nootropic, cerebrovasodilating, antihypoxic and psychostimulating effect. Improves impaired memory, increases the ability to concentrate, reduces fatigue and symptoms of depression, reduces spasticity of skeletal muscles caused by diseases or brain damage. Indications: Moderate to severe dementia in Alzheimer’s disease Dosage and administration: The method of application and dosing regimen of a particular drug depends on its form of release and other factors. The optimal dosage regimen is determined by the doctor. Compliance of the dosage form of a particular drug with indications for use and dosing regimen should be strictly observed. When taken orally, the initial dose for adults is 5 mg / day. (1-7days) In the future, the dose can be increased weekly by 5 mg. The average maintenance dose is 10-20 mg / day. The maximum dose is 20 mg / day. Contraindications: Hypersensitivity to memantine; severe liver failure; pregnancy; lactation period (breastfeeding); children and adolescents under 18 years of age (efficacy and safety of the drug have not been established). Carefully if: epilepsy, thyrotoxicosis, predisposition to develop seizures, simultaneous use of NMDA receptor antagonists (amantadine, ketamine, dextromethorphan), factors that increase urine pH (abrupt change in diet, for example, switching to vegetarianism, abundant intake of alkaline gastric buffers ), renal tubular acidosis, severe urinary tract infections caused by Proteus spp., myocardial infarction (history), heart failure, uncontrolled arterial hypertension, renal failure, mild or moderate liver failure (Child-Pugh class A and B). Warnings and precautions: Caution should be used in patients with epilepsy, renal failure, thyrotoxicosis, a history of convulsions, arterial hypertension, a history of myocardial infarction, heart failure. The concomitant use of memantine and NMDA receptor antagonists such as amantadine, ketamine or dextromethorphan should be avoided. These compounds act on the same receptor system as memantine, therefore adverse reactions (mostly CNS related) may occur more frequently and be more severe. Side effects: -Immune system: often – hypersensitivity reactions. -Mental: often – drowsiness; infrequently – confusion, hallucinations (mainly observed in patients with Alzheimer’s disease at the stage of severe dementia), the frequency is unknown – mental reactions. -Nervous system: often – dizziness, imbalance; infrequently – gait disturbance; very rarely – convulsions. -Cardiovascular system: often – increased blood pressure; infrequently – heart failure, venous thrombosis and / or thromboembolism .. -Digestive system: often – constipation; infrequently – vomiting, nausea; frequency unknown – pancreatitis. -Liver and biliary tract: often – elevated levels of “liver” enzymes; frequency unknown – hepatitis. -Hematopoietic system: the frequency is unknown – agranulocytosis, leukopenia (including neutropenia), pancytopenia, thrombocytopenia, thrombocytopenic purpura. -Other: often – headache, shortness of breath; infrequently – fungal infections, fatigue; frequency unknown – acute renal failure, Stevens-Johnson syndrome. Storage: Stote at a temperature not exceeding 30°C. Package: The carton box contains a 20 ml glass bottle, paper leaflet.
