Brufen Retard 800 mg 20 tablets
Available at Pharmaegy Pharmacy. Use as directed by your doctor.
Brufen Retard 800 mg, 20 Modified Release Film-Coated Tablets Composition Active ingredient: Ibuprofen 800 mg per tablet Description Brufen Retard is a non-steroidal anti-inflammatory drug (NSAID) with anti-inflammatory, analgesic, and antipyretic properties. It is used primarily for the treatment of rheumatoid arthritis, osteoarthritis, and various pain-related conditions. Indications for Use -Inflammatory Rheumatism: Rheumatoid arthritis (including juvenile всrheumatoid arthritis), ankylosing spondylitis, seronegative arthropathies. -Degenerative Rheumatism: Osteoarthritis, degenerative joint disease (knee and hip), polyarthritis, spondylosis. -Extra-articular Rheumatism: Myalgia, periarthritis, bursitis, tendinitis, tendovaginitis, low back pain, neuralgia. -Traumatology: Soft tissue injuries (sprains, strains), post-operative pain, toothache, pain after dental procedures. -Other Uses: Dysmenorrhea and as an adjunct therapy in infections with inflammation or fever. Dosage and Administration -Adults: 1 tablet (800 mg) twice daily, preferably in the evening after food with plenty of water. -Severe Cases: Additional ibuprofen (200-600 mg, not prolonged release) may be taken in the morning. -Paediatric Population: Not suitable for children under 12 years. -Tablets should be swallowed whole, not chewed, broken, or crushed. Contraindications -Hypersensitivity to ibuprofen or NSAIDs. -History of bronchospasm, urticaria, or allergic reactions to NSAIDs. -Third trimester of pregnancy. -Active or recurrent gastric/peptic ulcers, gastrointestinal bleeding. -Inflammatory bowel disease (Crohn’s disease, ulcerative colitis). -Severe liver impairment, renal impairment (creatinine clearance <30 ml/min). -Severe heart failure (NYHA III-IV). -Post-operative pain management after coronary bypass surgery. Precautions -Gastrointestinal Risks: Risk of ulcers, bleeding, and perforation; use with caution in elderly patients and those with a history of ulcers. -Cardiovascular Risks: Possible increased risk of thrombotic events, myocardial infarction, and stroke, especially at high doses (>2400 mg/day). -Renal Effects: Risk of renal impairment, especially in dehydrated patients, elderly, or those with pre-existing renal conditions. -Liver Function: Use with caution in patients with hepatic impairment. -Interactions: Increased risk of bleeding with anticoagulants, corticosteroids, and selective serotonin reuptake inhibitors. -Alcohol Use: Increases risk of gastrointestinal and central nervous system side effects. -Skin Reactions: Rare severe reactions like Stevens-Johnson syndrome; discontinue at first sign of skin rash or hypersensitivity. -Infections: May mask symptoms of infection, potentially delaying diagnosis and treatment. Pregnancy and Lactation -First and Second Trimester: Use only if necessary and at the lowest effective dose. -Third Trimester: Contraindicated due to risks of fetal cardiopulmonary toxicity, renal impairment, and prolonged labor. -Lactation: Not recommended; ibuprofen is excreted in breast milk. Side Effects Common: Nausea, dyspepsia, abdominal pain, diarrhea, headache, dizziness. Serious: Gastrointestinal bleeding, ulceration, heart failure, renal impairment, liver dysfunction, anaphylaxis, severe skin reactions. Neurological: Rare cases of aseptic meningitis, particularly in patients with autoimmune diseases. Storage Conditions Store at a temperature below 25°C. Keep in original packaging to protect from moisture and light. Keep out of reach of children. Packaging A carton box contains 2 blisters of 10 film-coated tablets (total: 20 tablets) and a package insert.
