Co-Aprovel – 150mg/12.5mg Film-Coated Tablets

Available at Pharmaegy Pharmacy. Use as directed by your doctor.

Intro: Co-Aprovel 150/12.5 is a potent combination antihypertensive medication produced by Sanofi. It combines Irbesartan (150mg), an Angiotensin-II Receptor Blocker (ARB), and Hydrochlorothiazide (12.5mg), a thiazide diuretic. This "power couple" of ingredients works by simultaneously relaxing the blood vessels and helping the kidneys eliminate excess salt and water, providing a comprehensive approach to lowering blood pressure. Indications: Essential Hypertension: Treating high blood pressure in adults when single-drug therapy is insufficient. Secondary Protection: Reducing the long-term risk of cardiovascular events such as stroke or myocardial infarction. Diabetic Nephropathy: Often used to protect kidney function in hypertensive patients with Type 2 diabetes. How to Use: Dosage: Usually one tablet daily. Administration: Can be taken with or without food. It is best to take it in the morning due to the diuretic effect (to avoid night-time urination). Consistency: Swallow the tablet whole with a glass of water at the same time each day. Crucial Rules: Pregnancy Contraindication: Strictly forbidden during pregnancy, particularly in the second and third trimesters, as it can cause serious harm or death to the fetus. Sulfa Allergy: Because it contains Hydrochlorothiazide, do not use if you have an allergy to sulfonamides (sulfa drugs). Kidney & Liver Monitoring: Not recommended for patients with severe renal impairment (CrCl < 30 ml/min). Regular monitoring of creatinine and potassium levels is essential. Hydration: Be cautious of excessive sweating, diarrhea, or vomiting, as dehydration can lead to an excessive drop in blood pressure (hypotension). Generic International Brands: Avalide (Original Reference), Irbetal Co, Karvezide.